Barbra Streisand used to be their favorite punching bag.
The episode " Canada On Strike" is a Take That aimed at The Writer's Guild of America's strike in attempt to get "all that Internet money." Notably, Parker and Stone are not members of the Guild.Even if Issac Hayes left the production for other reasons, note His son revealed 10 years later that someone within the church made the statement on his behalf while he was already on bad terms with Matt and Trey it's still pretty clear they were really upset. Chef is then brutally killed off by a mountain lion and a bear in the most gruesome way possible before the people that brainwashed Chef bring him back to life as Darth Chef. The rumor is hard to deny when the writers turned Chef into a brainwashed pedophile, using spliced in voice clips of Chef from earlier episodes. This led to an often denied rumor that Scientologist cast member Issac Hayes left the show as a result of their parodying of his religion. When telling the story of Scientology, they play it entirely straight and the Take That is actually them adding the caption at the bottom that this is what Scientologists actually believe.When it comes to Scientology on the other hand, they tend to up their Take Thats toward the celebrity followers as well as the teachings. While Parker and Stone love to poke fun at religions from Catholicism, Judaism, Mormons etc., you often get a balanced view of idiosyncrasies for that religion offset by practitioners being pretty decent.Including one from " Smug Alert! " and Team America: World Police. Clooney also had a few Take Thats leveled at him.But at least Family Guy has managed to keep the avails limited to every other episode or so, as opposed to South Park that's got at least one per episode. The show also saved some room for a self-deprecating Take That at itself when one character states that at least Family Guy "doesn't get all preachy and up its own ass with messages." Which turned out to be Hilarious in Hindsight in light of what came later on Family Guy.The episodes also attacked its own channel, Comedy Central, for "pussing out" and refusing to allow them to air a cartoon depiction of Muhammad, which the episode argued was necessary to preserve America's freedom of speech.He apparently took it back when he was in a talk show replying to the questioned rivalry with "They're on cable TV, who cares?" note He used a snarky tone, possibly implying that his shows are more accessible than South Park Seth MacFarlane has responded that this is pretty much an accurate description of how the show is written. The bulk of the episodes attacked Family Guy, portraying the show as little more than an unconnected string of meaningless pop culture references selected at random by Manatees.